KMID : 0363419990130020149
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Journal of Korean Oriental Pediatrics 1999 Volume.13 No. 2 p.149 ~ p.170
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Otitis Media is one of the Most Common Disease of Otolaryngology and Pediatrics
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Park Eun-Jung
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Abstract
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The author measured IL-2, IL-4, IL-6, TNF-${\alpha}$ and total protein(TP) level of middle ear effusion(MEE) of 24 ears - 13 ears of them had treated by antibiotics, 11 of them by Kami-hyunggyeyungyotang - of pediatric recurrent otitis media with effusion(PROME) using ELISA assay, and compared the level of cytokines(pg/ml)/TP(mg/dl). And investigated the clinical finding in those children. The results were obtained as follows: 1. The level of IL-2£¯TP in Kami-hyunggyeyungyotang group was significantly higher than that in antibiotics group(P¡´0.05). 2. The level of IL-4/TP in Kami-hyunggyeyungyotang group was significantly higher than that in antibiotics group(P¡´0.0l). 3. The level of IL-6/TP in Kami-hyunggyeyungyotang group was significantly lower than that in antibiotics group(P¡´0.05). 4. The level of TNF-${\alpha}$/TP in Kami-hyunggyeyungyotang group was significantly lower than that in antibiotics group(P¡´0.01) 5. 79.1% of children with recurrent otitis media with effusion(ROME) were also complicated to chronic sinusitis. The children¡¯s t-test was used to make a statistical comparison between the groups. According to above results, Kami-hyunggyeyungyotang is considered to be used for treatment ¡¯¡¯recurrent otitis media with effusion¡¯¡¯ by control produce of cytokines which are connected with inflammatory reaction.
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KEYWORD
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